In practical engineering, the properties of low-cost navigation system determine that it can't work at all attitudes. When air-to-ground missile launched in high-altitude to attack short-range targets, the prominent characteristic of generalized trajectory-shaping guidance law (GTSGL) could result in pitching angle beyond the measurement range of gyro sensor in glide trajectory. Concerning this problem, a new trajectory-shaping guidance law with multi-constraint was proposed in this paper. This new guidance law can limit pitching angle by adding pitching angle restriction item on the basis of GTSGL. Simulation result shows that the proposed midcourse guidance law can effectively limit the pitching angle and meet impact position and angle constraints, which has more ideal midcourse performance under engineering constraints.