Cruise missile has become trump card for U. S. troops returning to Asia-Pacific. It poses a great threat to air defense system on the southeast coastal areas of our country. Firstly, feasibility of portable missile intercepting subsonic stealth cruise missile was analyzed overall Then the mathematical models were established and kill probability of intercepting cruise missile was simulated under different attack condition according to target vulnerability, missile meeting target and the kill probability. At last, effective conclusions were obtained that the third generation portable missile can intercept subsonic stealth cruise missile It's useful to provide a reference for troops training.