In the overall design stage, how to optimize the overall indicator of the fuze and the warhead should be studied and discussed. In the article, the mathematical models of the warhead fragment dynamic dispersion and the fuze start-up angle were built for fragmentation warhead and fixed beam fuze. From the perspective of optimum fuze warhead coordination, the fuze warhead integration design was performed and a method of fuze start-up angle design was proposed. The simulation result and the engineering application demonstrate that the fuze warhead coordination can be effectively optimized in the overall design stage with this method.