Focused on effectively damaging air targets, a damage effect comparison between focusing warhead and conventional blast fragmentation warhead was researched. The simulation system of damage assessment of fragment warhead to air target was devel-oped. Using the system, the number of fragments hit on the missile was calculated and the damage under the same initial ammuni-tion target interaction conditions was shown. The number of fragments hit on missile by focusing warhead is much more than hit by conventional blast fragmentation warhead, and the focusing warhead can cause cutting damage. The simulation experiment was conducted to compare synergetic damage effect of combined blast and fragments of focusing warhead and conventional blast frag-mentation warhead. Damage efficiency of focusing warhead is much higher. The research method and research results can supply reference to deep study of focusing warhead.