Based on rocket-powered wing-fuselage combination, the nose camber, airfoil camber and wing torsion angle were defined as three configuration characteristic parameters. In order to investigate the effect of hypersonic shock wave lifting body/surface on lift-drag ratio of the wing-fuselage combination, the design rules adaptable to near-space hypersonic cruise and optimizing configuration generated by them were presented. The research indicates coupling shock wave lifting body with surface is able to meet the aerodynamic requirements of both hypersonic cruise at low angle of attack and low speed flight at high angle of attack, and then wing-fuselage combination configuration optimization can be realized.