For analyzing effect of some factors on the ship-to-air missile miss distance against anti-ship missile of snake maneuver, the 3-D movement simulation models for both missiles were built. The simulation results prove that the main reasons affecting miss distance are radius, section distance, target altitude, course-shortcut, radome slope, turning rate and control system time constant, control system order. The achievements of this paper are believed to benefit the analysis of fighting efficiency and combat employment.