In order to provide references for the design or optimization of shaped charge warhead structure, the ANSYS/LS-DYNA finite element software and ALE method were applied to explore the penetration process of three kinds of liner structures with different wall thickness types. The simulation results show that in a certain wall thickness range, with the increase of liner wall thickness, favorable height of burst shows relatively high stability; when the wall thickness is the same, with the increase of the height of burst, the penetration depth increases first and then decreases. The research results have certain guiding significance for the application of shaped charge warhead in engineering.