In order to research the effect of laser jamming on precision guide weapons, the system components, the operational process and the result analysis for the simulation experiment of laser jamming on seeker were introduced. Whether effective jamming is formed or not is judged by whether CCD can track the target correctly. When researching the influence on seeker tracking the target, the continuous and pulsed laser was used to designate part of CCD, the power, frequency and incidence angle of the laser were altered. Finally, one of the best conditions to jam the IR seeker with laser was given.