In order to improve the anti-jamming capability of air-to-ground image-guided missile, indicia were added in the guiding image, the indicia were used for noise estimation, then filtering to remove noise by the method of local statistics. This method achieves to remove noise of air-to-ground image-guided missile in a complex electromagnetic environment. The simulation results show that in a certain signalto-noise ratio (SNR) range, the method can be used to remove part of noise, and increase the probability of the human eye to identify a target, so it can enhance air-to-ground image-guided missile's attack efficiency without changing the existing hardware.