In order to design a novel hypersonic cruise vehicle, the test vehicle of HIFIRE Flight 1 was modified to achieve better aerodynamic performance numerically. The obtained results show that the upper surface and airfoil greatly affect aerodynamic performance of the vehicle. The lift-to-drag ratio increases continuously with the decrease of the area of the upper surface. Furthermore, without the airfoil, the lift-to-drag ratio increases with the increase of the Mach number. The wing with the waverider characteristics provides a larger lift-to-drag ratio. With the increase of the Mach number, the lift-to-drag ratio of Model 3 first increases, and then decreases. When the Mach number is 8, the lift-to-drag ratio is the largest.