Aiming at the multi-position combined attack combat mission of mobile shore-to-ship missile forces, in order to realize the combat intention of effectively controlling the target sea area, this paper analyzes the factors affecting the deployment efficiency of shore-to-ship missile weapon system (SSMWS), gives the related concepts such as cooperative damage capability, damage area and damage effects, and on the basis of the basic idea of Monte Carlo method,by transforming the damage area of SSMWS into several discrete points, a multi-position shore-to-ship missile strike optimization model and a SSMWS fire coverage area simulation model based on the maximum cooperative damage capability are established. Through case analysis and genetic algorithm, a strike optimization scheme is obtained, which verifies the effectiveness of the model and could provide support and references for shore-to-ship missile deployment decisions.