Aiming at uncertain nonlinear BTT missile control systems, an adaptive control scheme of fuzzy gauss function neural network was proposed for the system. The method is that the uncertainties should be combined to one in the design procedure, fuzzy-neural network is designed to approximate the uncertainty, then sliding mode control and adaptive fuzzy-neural network control theory are used to design the controller, the Lyapunov stability theory is used to guarantee the closed-loop stability and derive the adaptive rule. Finally, the results of simulation demonstrated the effectiveness of the proposed method.