The target search strategy of air-ship missile under the condition of bearing-only target designation was studied in this contribution. The method of analysis, modeling and simulation was used for studying the models of bearing-only target designation, and the target region search method of anti-ship missile, as well as the direction of target region search and the amount of missile consumed were put forward. Finally, the simulation on target region calculation, search region extraction, planning of the self-control route of missile, and target region search was carried out to verify the feasibility of the strategy discussed.