The vibration characteristic of vessel was analyzed by measuring acceleration signal of three measuring points on the vessel and cylindrical shell mode analysis. Theory analysis and experiment data indicates: within quantity explosive of the experiment, vibration frequency primarily distributes within 11-order dominant frequency; High-order frequency chiefly distributes in vibration frequency of the vessel's center section, and with the increase of internal blast loading, dominant frequency is inclined to breathing frequency. In order to avoid resonance and increase safety of the vessel, we can raise breathing frequency by welding reinforce layer on the vessel's center section; Far from vessel's center section, the primary vibration frequency of the vessel is low-order frequency. The low-order frequency is excited easily in the small quantity experiment. We can reduce asymmetric structure and hole near the vessel's center section for the safety of the vessel.