In order to evaluate the damage ability of anti-ship missiles on surface ships based on cluster munitions technology, a simulation research on combat damage effect was carried out. The mathematic model of surface warship was established to quantify the damage ability index of anti-ship missile on surface warship, Monte-Carlo method is used to simulate the damage effect of anti-ship missile on surface warship for evaluating the damage degree of the system. The attack effect of a certain munitions was analyzed. The study results can provide reference for the evaluation of the damage effectiveness of anti-ship missiles based on the cluster munitions technology.