In this paper, LS-DYNA was used to investigate the penetration of preformed tungsten fragments into moderately thick steel targets under oblique penetration. By comparing and analyzing the damage pattern of projectile target and the time history curve of fragment velocity, the influence law of incident angle and initial kinetic energy on the penetration performance of fragment was obtained. The result shows: the ballistic limit of fragment increases with the increase of incidence angle; In the same speed, with the increase of incident angle of cylindrical fragment entrance aperture increasing, hole shape becomes irregular. The wear time becomes longer. The residual velocity and residual kinetic energy become smaller, and the velocity attenuation and kinetic energy attenuation are more serious. In the case of 1 300 km/s, when the angle of incidence increases from 10° to 50°, the crater volume increases, and the crater volume decreases sharply under the 60° condition: At the same incidence angle, the initial velocity increases. The fragment penetration time becomes shorter, and the crater volume increases. It is slightly larger than the crater size formed under the penetration.