The numerical method based on overlapping structured grids is used to simulate unsteady flow of tactical missile with large slenderness ratio pulled up from a level flight to a high angle-of-attack (AOA). And the results are analyzed and compared with the static results of several selected AOA. The obvious difference is that the lateral value in static state is larger, while the longitudinal value in dynamic state is larger. The results show that in tactical engineering development, for the best effect,'dynamic-static match' mode should be fully considered in aerodynamic design.