In the process of constructing the ship damage matrix under the conditions of high-dimensional missile terminal parameters，the traditional uniform sampling method has insufficient accuracy due to the limited computing resources.To address this issue，this paper proposes a non-uniform high-precision damage matrix construction method based on the sensitivity analysis of ship damage characteristics.This method first uses the empirical formulas to quickly calculate the probability of damage at discrete explosion points in a ship and obtain the sensitivity distribution of the damage probability space.An then，the sensitive areas within the ship are projected onto the missile terminal parameter space by combining the firing line method and the pixel method to determine the parameter sensitive intervals.On this basis，a probability-weighted non-uniform sampling strategy is adopted to adaptively allocate the sampling resources to the high-sensitive areas while also considering global exploration.Simulation experiments show that，compared with the traditional uniform sampling method，the average prediction deviation mean，median and quartile range of damage matrix constructed by the proposed method are reduced by approximately 50.9%，57.8% and 52.9%，repectively，under the same number of sampling points.The proposed method can effectively improve the accuracy of damage matrix construction under the constraint of limited computing resources.