Because of the accuracy requirements of the precision-guided weapon systems and uncertainty of a single sensor, currently guided weapons systems mostly use multi-source information fusion. Simulation of multi-source information fusion system of stratified multistage blackboard is on the basis of analysis of multi-source information characteristics of the guided weapons It is designed that information fusion functional model, the hierarchical model, as well as the overall framework. The process of multi-source information is given. With the combination of guided process, the target is identified by the use of the DS algorithm. Simulation results show that the fusion system is value to improve the accuracy of the guided weapons systems.