In this paper, according to the characteristics and demands of wind tunnel virtual flight simulation system, a control system of model missile pitch, yaw and roll channels for wind tunnel virtual flight simulations was designed. In missile pitch channel, the three-loop control structure was used for angle of attack command control. In missile roll channel, the two loop control structure was used for angle of roll attitude command control. In missile yaw channel, angle of sideslip was controlled by hydraulic driving device in open loop. The control system gains were designed through pole-placement method. Finally, the digital simulation was carried out and the design results were validated. According to the digital simulation results, the designed pitch and roll channel close-loop control system can meet the demand of wind tunnel virtual flight simulation in time domain or frequency domain.