Vulnerability analysis of runway is the basis of power design and assessment for anti-runway weapon. Target characteristics were analyzed by investigating target characteristics of runway. Based on computer simulation and Monte Carlo method, the vulnerability analysis method for runway was established including mathematic model of runway, flying off and landing mode, cluster warhead dispersing model and searching algorithm. Vulnerability analysis software of runway was developed based on the method, and the applied example was illustrated. The establishment of vulnerability analysis method is helpful to the design and assessment of anti-runway weapon.