For communication between the computer and field nodes, a data communication system based on the characteristics ofPC104 bus architecture and the advantage of CAN bus was designed FPGA was taken as the main control unit and CAN bus com-munication network composed of the C8051F040 MCU's internal CAN controller and the external CAN bus transceiver TJA1040 totest the data transmission performance, achieving the data's security, real-time, reliable transmission. Now, it has been applied tothe test and measurement system in industrial control field.