Based on the need of cross-linking between flying control system and integrated navigation system of aircraft, the 1553B data bus communication interface was implemented by using DSP+FPGA. The setup method for RT initialization and data receiv-ing was introduced in detail from aspects of hardware connection, sequential logic and upper software design. Finally, the proposed method was programmed and tested according to the engineering application. Testing result reflects that the designed method is reasonable and the proposed method has many advantages over the existing ones such as design flexibility and high redundancy.