According to the characteristic of the network centric ship-to-air missile system, the information flow of campaign process was analyzed, the ability of battlefield awareness, coordinated guidance coverage and thermodynamic power strike were analyzed, and a model for the anti-missile capability of the network centric ship-to-air missile was set up based on cooperative information. The anti-missile capability of the network centric ship-to-air missile was evaluated by an example, providing a method for air and missile defense of ship under the information condition.