Based on virtual prototype technology, the system dynamics for missile launch of marching vehicle with active control suspension was studied. An air-defense missile weapon system's rigid-flexible coupling dynamic simulation model was built in Adams/View. By means of Matlab/Simulink, the fuzzy adaptive control strategy was created for active suspension. Meanwhile, the system's co-simulation model was constructed as well. Marching dynamic simulation under three different velocities was done on C, D and E level road separately. The dynamic data of launcher's random response and missile's motion characteristics was obtained. It shows that this suspension can effectively reduce initial disturbance's influence on launching process, so it is effective for marching launch.