A designation of shaped charge with tungsten copper alloy liner was proposed based on penetration destroy in water. Through experiment study between tungsten copper alloy liner and copper liner, jetting penetration law in water was obtained, including jet velocity attenuation law in water and the effect of penetrating into target. Experimental results show that jetting of tungsten copper alloy liner can keep higher surplus velocity than copper liner in water, so the effect of damage on target is more powerful. The result of study has certain referential value for project design.