In order to study the damage effect of runway blasting at different depth, the numerical simulation of blasting was carried out to estimate different blasting depth at runway with AUTODYN software. Under the simulation conditions, it was revealed that the depth of charge was a factor controlling the damage radius and crater blasting volume. The calculations of fragmentation indicated that the average damage radius and crater blasting volume increased when the depth of charge increased as observed in practical blasting. The simulation shows that at the optimal blasting depth of the explosive charge, the crater blasting volume reaches the maximum. The relation between the depth of charge and damage parameter has been obtained.