A fuze warhead system model based on virtual prototype of air-to-air missile guidance system was built for studying the missile terminal destroy process at target, fuze-warhead coordination effect and fuze warhead parameters optimization. Based on the real-time trajectory information of guidance simulation output and three-dimensional object shape of target, the fuze detection, de-layed explosion, warhead dispersion and damage effectiveness calculation were constructed to really display terminal encounter process. The fuze warhead simulation model was connected with guidance simulation subsystem and visual simulation subsystem to form integrated air-to-air missile virtual prototype. The virtual prototype ran well and the rationality of fuzzed warhead subsystem simulation model was validated.