In order to complete the ground integrated test of a certain weapon system, this paper used PXI bus technology for the design and implementation of the optical fiber homing fire control device. By studying the characteristics of the weapon system, this paper designed and implemented hardware and software structure of homing fire control device, and solved the key technologies such as real-time response, remote control. The simulation of weapon system launch system on the ground were completed. Tests showed that homing fire control device had been successfully applied in the system integration test. The performance was good, and it could work stably.