The traditional design method of aircraft cable had the problem as low design efficiency, large error, unreasonable cable way, difficult to estimate the quality characteristics in the design stage and so on. Based on the study of the principle of cable design and the 3D cable design module of Creo, the paper gave a cable 3D collaborative design method, which improved the efficiency and the rationality of cable network layout, and it is of great significance to the design of aircraft cable. Finally, the paper took an certain aircraft cabin cable design as an example to verify the feasibility of the method.