Wind tunnel tests were conducted on an air-to-air missile with folded tails under specific flight conditions, and the aerodynamic loads during the deployment process were given. The effects of the aerodynamic loads on the deployment process were analyzed, and CFD calculations were performed to explore the mechanism. Results demonstrate that aerodynamic loads accelerate the deployment process for tails on the windward side under given flight conditions, but decelerate the process for tails on the leeward side in transonic regime, and first accelerate then decelerate the process in supersonic regime.