In order to study the influence of the Piercing-Blasting warhead penetrating surface vessel target with attack angle, used finite software LS-DYNA to simulate the process of the two-stage piercing-blasting warhead attacking double equivalence target, analyzed the influence of residual velocity, shell strength, speed declination and stroke different of the two stage warhead at attack angles. The results show that when the attack angle increase, it has little affect to the penetration of pre-stage, but the last stage warhead facing austere influence; When attack angle increase, the deformation of last stage warhead aggravate; The attack angle is beneficial to increase the stroke different between the pre-stage and last stage warhead. The results can provide reference for new warhead design.