Aero-thermal-structure coupled influence is one of most important problems that high speed vehicles face. The coupled problem is simplified by relationship among these sub disciplines. Based on unidirectional coupling influence among aerodynamic heating, transient heat transfer, thermal structure, thermal mode and thermal flutter analysis, a multidisciplinary integrated analysis platform was established. Aiming at time-consuming problem involving multi-disciplines, adaptive response surface method was employed to optimize the aerothermal-structure coupled problem. The result indicates the mass of lifting surface structure is reduced under a higher flutter speed. Keywords: high speed vehicles; aero-structure-thermal coupled; optimization design; unidirectional coupling analysis