In order to improve the performance of the surface-to-air missile, the integrated guidance and control model of the missile was established. According to the dynamic equation of the missile and the relative motion of the missile and the target, obtain the relationship between the relative velocity perpendiculars to the LOS, and see the coupling items as the uncertainty, then establish the integrated guidance and control model of the surface-to-air missile. This model has strict feedback cascade form, and import the guidance information to the control system. The control variable can be obtained by ways of backstepping from the relative movement of the missile and the target.