This paper first introduced the skimming off the target fault of the Laser-Guided Missile Weapon System, under the condition of certain environment using seeker output slope spread and inefficiency caused abnormal seeker tracking ability decline, and its mechanism were analyzed, and the second presents a seeker output slope temperature compensation algorithm, the design of the algorithm steps and beneficial effects, at last, by mathematical simulation, hardware-in-the-loop simulation and flight test results show that take the temperature compensation algorithm, can effectively solve the skimming off the target fault, accuracy can be obviously improved.