A compound control system of rolling high-speed kinetic energy missile based on impulse thrust/aerodynamic control is designed. Firstly, the mathematical model of rolling high-speed kinetic energy missile is established, then the working flow of the composite control system of impulse thrust/aerodynamic control is described, and the ignition strategy of the impulse engine is designed. Finally, the composite control method is verified and analyzed by a simulation example. The simulation results show that the designed composite control system can effectively reduce the initial disturbance of high-speed rolling kinetic energy missile at launch, and has certain application value.