This paper took the requirements of the man-machine-environment system evaluation method of missile launch vehicle as the traction, aiming at the characteristics of man-machine close combination, then treat man and missile launch vehicle as a whole system to comprehensively analyze and study. Using the fuzzy analytic hierarchy process to calculate the index weight, which influence ergonomic factors, on this basis, the initial data of objective data and subjective indexes were obtained by test data, simulation data, measurement results and expert scoring method, combining with whitening weight function to complete the evaluation of the ergonomics index, finally the scientific evaluation of the man-machine-environment system design results of missile launch vehicle was realized.